While scavenging the deep ends of a derelict space station, a group of young space colonizers come face to face with the most terrifying life form in the universe.

A listless Wade Wilson toils away in civilian life with his days as the morally flexible mercenary, Deadpool, behind him. But when his homeworld faces an existential threat, Wade must reluctantly suit-up again with an even more reluctant Wolverine.

Returning to her home planet, an infamous outlaw forms an unexpected alliance with a team of unlikely heroes. Together, they battle alien monsters and dangerous bandits to find a missing girl who holds the key to unimaginable power.